Altered functional brain states predict cognitive decline 5 years after a clinically isolated syndrome.
Mult Scler
; 28(12): 1973-1982, 2022 10.
Article
em En
| MEDLINE
| ID: mdl-35735004
ABSTRACT
BACKGROUND:
Cognitive impairment occurs in the earliest stages of multiple sclerosis (MS) together with altered functional connectivity (FC).OBJECTIVE:
The aim of this study was to investigate the evolution of dynamic FC states in early MS and their role in shaping cognitive decline.METHODS:
Overall, 32 patients were enrolled after their first neurological episode suggestive of MS and underwent cognitive evaluation and resting-state functional MRI (fMRI) over 5 years. In addition, 28 healthy controls were included at baseline.RESULTS:
Cognitive performance was stable during the first year and declined after 5 years.At baseline, the number of transitions between states was lower in MS compared to controls (p = 0.01). Over time, frequency of high FC states decreased in patients (p = 0.047) and increased in state with low FC (p = 0.035). Cognitive performance at Year 5 was best predicted by the mean connectivity of high FC state at Year 1.CONCLUSION:
Patients with early MS showed reduced functional network dynamics at baseline. Longitudinal changes showed longer time spent in a state of low FC but less time spent and more connectivity disturbance in more integrative states with high within- and between-network FC. Disturbed FC within this more integrative state was predictive of future cognitive decline.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Disfunção Cognitiva
/
Esclerose Múltipla
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Mult Scler
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
França