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Pharmacokinetics of carprofen following single and repeated intravenous administrations of different doses in sheep.
Corum, Orhan; Coskun, Devran; Durna Corum, Duygu; Ider, Merve; Yildiz, Ramazan; Ok, Mahmut; Uney, Kamil.
Afiliação
  • Corum O; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Turkiye.
  • Coskun D; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Siirt, Siirt, Turkiye.
  • Durna Corum D; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Turkiye.
  • Ider M; Department of Internal Medicine, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkiye.
  • Yildiz R; Department of Internal Medicine, Faculty of Veterinary Medicine, University of Mehmet Akif Ersoy, Burdur, Turkiye.
  • Ok M; Department of Internal Medicine, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkiye.
  • Uney K; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkiye.
J Vet Pharmacol Ther ; 45(5): 481-487, 2022 Sep.
Article em En | MEDLINE | ID: mdl-35748159
ABSTRACT
The aim of this study was to determine the pharmacokinetics of carprofen following single and repeated intravenous (IV) administrations at 1.4 and 4 mg/kg doses in sheep. The study was carried out on twelve sheep in two experiments as single- and multiple-dose pharmacokinetics. In experiment 1, carprofen was administered via IV at single doses of 1.4 (n = 6) and 4 mg/kg (n = 6) in a randomized parallel design. In experiment 2, the same dose groups in experiment 1 following the 21-day washout period received intravenously carprofen every 24 h for 5 days. Plasma concentrations were measured using high-performance liquid chromatography-UV and analyzed by a two-compartment open model. After the single administration of 1.4 mg/kg dose, the t1/2α , t1/2el , MRT, ClT , Vdss , and AUC were 0.62 h, 27.57 h, 38.78 h, 2.72 ml/h/kg, 105.26 ml/kg, and 515.12 h*µg/ml, respectively. Carprofen at a single dose of 4 mg/kg showed prolonged t1/2el and MRT, and increased Vdss . On day 5 after the repeated administration of the 1.4 mg/kg dose, the t1/2α , t1/2el , MRT, ClT , Vdss , and AUC were 1.12 h, 57.48 h, 82.18 h, 0.55 ml/h/kg, 45.43 ml/kg, and 2532 h*µg/ml, respectively. Carprofen at a repeated dose of 4 mg/kg showed increased ClT and Vdss and decreased AUC/dose. Although the long t1/2ʎz in single and multiple IV dose studies suggest the possibility of its effective use, the IV route may not be practical in sheep. Therefore, oral and subcutaneous routes of carprofen in sheep would be more valuable in clinical settings.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carbazóis Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Vet Pharmacol Ther Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carbazóis Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Vet Pharmacol Ther Ano de publicação: 2022 Tipo de documento: Article