Differences in New Variant of Concern Replication at Physiological Temperatures In Vitro.

Stauft, Charles B; Sangare, Kotou; Wang, Tony T

Stauft, Charles B; Sangare, Kotou; Wang, Tony T.

Afiliação

Stauft CB; Division of Viral Products, Center for Biologics Evaluations and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.
Sangare K; Division of Viral Products, Center for Biologics Evaluations and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.
Wang TT; Division of Viral Products, Center for Biologics Evaluations and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.

J Infect Dis ; 227(2): 202-205, 2023 01 11.

Article em En | MEDLINE | ID: mdl-35759271

ABSTRACT

ABSTRACT

Using multiple cell types and isolates of Delta and Omicron variants of SARS-CoV-2, we report differences in virus production, replication, and infectivity in vitro. Ancestral and Delta SARS-CoV-2 variant exhibit reduced virus production and replication at 34°C compared to 37°C while Omicron replication is balanced between temperatures.

Assuntos

COVID-19; Humanos; SARS-CoV-2/genética; Temperatura

Palavras-chave

COVID-19; Delta variant|; Omicron variant; SARS-CoV-2; new variant of concern; replication; temperature sensitivity; transmission

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 Limite: Humans Idioma: En Revista: J Infect Dis Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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