Targeted next-generation sequencing identifies a novel nonsense mutation in ANK1 for hereditary spherocytosis: A case report.
World J Clin Cases
; 10(15): 4923-4928, 2022 May 26.
Article
em En
| MEDLINE
| ID: mdl-35801015
ABSTRACT
BACKGROUND:
Hereditary spherocytosis (HS) is characterized by anemia, jaundice, splenomegaly, and cholelithiasis, and is caused by abnormal genes encoding red blood cell membrane components. The most common mutations found in HS are in the ANK1 gene. CASESUMMARY:
A 4-mo-old girl was admitted to our hospital with pallor that had lasted for more than 2 mo. She presented with jaundice, anemia and splenomegaly. A heterozygous mutation of ANK1 (exon23 c.G2467Tp.E823X) was identified, and the mutation was determined to be autosomal dominant. This mutation is linked to the relatively serious anemia she had after birth; this anemia improved with age.CONCLUSION:
The utilization of next-generation sequencing may assist with the accurate diagnosis of HS, especially in atypical cases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
World J Clin Cases
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China