Hypermethylation of Mig-6 gene promoter region inactivates its function, leading to EGFR/ERK signaling hyperphosphorylation, and is involved in arsenite-induced hepatic stellate cells activation and extracellular matrix deposition.

Wang, Dapeng; Ruan, Wenli; Fan, Lili; Xu, Huifen; Song, Qian; Diao, Heng; He, Rui; Jin, Ying; Zhang, Aihua

Wang, Dapeng; Ruan, Wenli; Fan, Lili; Xu, Huifen; Song, Qian; Diao, Heng; He, Rui; Jin, Ying; Zhang, Aihua.

Afiliação

Wang D; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang 550025, Guizhou, China. Electronic address: wojiushiwdp@126.com.
Ruan W; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang 550025, Guizhou, China; Tongren Center for Disease Control and Prevention, Tongren 554300, Guizhou, China.
Fan L; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang 550025, Guizhou, China.
Xu H; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang 550025, Guizhou, China.
Song Q; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang 550025, Guizhou, China.
Diao H; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang 550025, Guizhou, China.
He R; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang 550025, Guizhou, China.
Jin Y; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang 550025, Guizhou, China.
Zhang A; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang 550025, Guizhou, China. Electronic address: aihuagzykd@163.com.

J Hazard Mater ; 439: 129577, 2022 10 05.

Article em En | MEDLINE | ID: mdl-35850069

Assuntos

Arsênio; Arsenitos; Arsênio/toxicidade; Arsenitos/toxicidade; Receptores ErbB/genética; Receptores ErbB/metabolismo; Matriz Extracelular/metabolismo; Células Estreladas do Fígado/metabolismo; Humanos; Sistema de Sinalização das MAP Quinases; Regiões Promotoras Genéticas

Palavras-chave

Arsenite; DNA methylation; EGFR/ERK signaling; Liver fibrosis; Mitogen-inducible gene-6

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arsênio / Arsenitos Limite: Humans Idioma: En Revista: J Hazard Mater Assunto da revista: SAUDE AMBIENTAL Ano de publicação: 2022 Tipo de documento: Article

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