Packaging of DNA origami in viral capsids: towards synthetic viruses.
Nanoscale
; 14(32): 11535-11542, 2022 Aug 18.
Article
em En
| MEDLINE
| ID: mdl-35861608
ABSTRACT
We report a new type of nanoparticle, consisting of a nucleic acid core (>7500 nt) folded into a 35 nm DNA origami sphere, encapsulated by a capsid composed of all three SV40 virus capsid proteins. Compared to the prototype reported previously, whose capsid consists of VP1 only, the new nanoparticle closely adopts the unique intracellular pathway of the native SV40, suggesting that the proteins of the synthetic capsid retain their native viral functionality. Some of the challenges in the design of such near-future composite drugs destined for gene delivery are discussed.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus
/
Capsídeo
Idioma:
En
Revista:
Nanoscale
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Israel