Antiproliferative Ruthenium Complexes Containing Curcuminoid Ligands Tested In Vitro on Human Ovarian Tumor Cell Line A2780, towards Their Capability to Modulate the NF-<i>&#954;</i>BTranscription Factor, FGF-2 Growth Factor, and MMP-9 Pathway.

Leskovská, Janka; Miklásová, Natalia; Kubelac, Paul Milan; Achimas-Cadariu, Patriciu; Valentová, Jindra; Markuliak, Mário; Fischer-Fodor, Eva

Antiproliferative Ruthenium Complexes Containing Curcuminoid Ligands Tested In Vitro on Human Ovarian Tumor Cell Line A2780, towards Their Capability to Modulate the NF-κBTranscription Factor, FGF-2 Growth Factor, and MMP-9 Pathway.

Leskovská, Janka; Miklásová, Natalia; Kubelac, Paul Milan; Achimas-Cadariu, Patriciu; Valentová, Jindra; Markuliak, Mário; Fischer-Fodor, Eva.

Afiliação

Leskovská J; Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Kalinciakova 8, 83104 Bratislava, Slovakia.
Miklásová N; Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Kalinciakova 8, 83104 Bratislava, Slovakia.
Kubelac PM; Institute of Oncology "Prof.Dr.I.Chiricuta", RO-400015 Cluj-Napoca, Romania.
Achimas-Cadariu P; Department of Oncology, "Iuliu Hatieganu" University of Medicine and Pharmacy, RO-400012 Cluj-Napoca, Romania.
Valentová J; Institute of Oncology "Prof.Dr.I.Chiricuta", RO-400015 Cluj-Napoca, Romania.
Markuliak M; Department of Oncological Surgery and Gynecological Oncology, "Iuliu Hatieganu" University of Medicine and Pharmacy, RO-400012 Cluj-Napoca, Romania.
Fischer-Fodor E; Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Kalinciakova 8, 83104 Bratislava, Slovakia.

Molecules ; 27(14)2022 Jul 18.

Article em En | MEDLINE | ID: mdl-35889441

Assuntos

Antineoplásicos; Curcumina; Neoplasias Ovarianas; Rutênio; Antineoplásicos/farmacologia; Linhagem Celular Tumoral; Curcumina/uso terapêutico; Diarileptanoides; Feminino; Fator 2 de Crescimento de Fibroblastos; Humanos; Ligantes; Metaloproteinase 9 da Matriz; Neoplasias Ovarianas/tratamento farmacológico; Rutênio/farmacologia

Palavras-chave

FGF-2; MMP-9; NF-κB; bisdemethoxycurcumin (BDMC); cytotoxicity; ruthenium(II) complexes; syringaldehyde curcumin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Rutênio / Curcumina / Antineoplásicos Limite: Female / Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Eslováquia

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