Benefits of tolvaptan on early dyspnea relief in patients with acute heart failure: A meta-analysis.
Clin Cardiol
; 45(10): 995-1001, 2022 Oct.
Article
em En
| MEDLINE
| ID: mdl-35916355
ABSTRACT
Considering the prevalence of dyspnea in acute heart failure (AHF), its reduction is important to both patients and caregivers. This meta-analysis was performed to determine the efficacy and safety of tolvaptan on early dyspnea relief in patients with AHF. A systematic search was made of PubMed, Embase, Web of Science, Cochrane Library, and clinicaltrials.gov, without language restrictions. Randomized controlled trials (RCTs) on treatment of AHF with tolvaptan, compared with placebo or blank, were reviewed. Studies were pooled to relative risk (RR), with 95% confidence interval (CI). Five RCTs (enrolling 4857 participants) met the inclusion criteria. Tolvaptan presented significant effects on 12 h dyspnea relief (RR 1.98; 95% CI 1.24-3.15; p = .004), 24 h/day 1 dyspnea relief (RR 1.15; 95% CI 1.07-1.24; p = .0003), 48 h dyspnea relief (RR 1.20; 95% CI 1.06-1.36; p = .004), and 72 h dyspnea relief (RR 1.18; 95% CI 1.02-1.37; p = .03). No significant increase was noticed in the incidence of worsening renal function in tolvaptan group (RR 1.10; 95% CI 0.87-1.39; p = .43). Tolvaptan treatment significantly improved patient-assessed dyspnea early and persistently in patients with AHF.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dispneia
/
Tolvaptan
/
Insuficiência Cardíaca
Tipo de estudo:
Clinical_trials
/
Etiology_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Clin Cardiol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China