Neuroprotective Effect of Dexmedetomidine against Postoperative Cognitive Decline via NLRP3 Inflammasome Signaling Pathway.

Cho, Inja; Koo, Bon-Nyeo; Kim, So Yeon; Park, Sujung; Kim, Eun Jung; Kam, Eun Hee; Kim, Jeongmin

Cho, Inja; Koo, Bon-Nyeo; Kim, So Yeon; Park, Sujung; Kim, Eun Jung; Kam, Eun Hee; Kim, Jeongmin.

Afiliação

Cho I; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
Koo BN; Anesthesia and Pain Research Institute, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
Kim SY; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
Park S; Anesthesia and Pain Research Institute, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
Kim EJ; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
Kam EH; Anesthesia and Pain Research Institute, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
Kim J; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.

Int J Mol Sci ; 23(15)2022 Aug 08.

Article em En | MEDLINE | ID: mdl-35955939

Assuntos

Disfunção Cognitiva; Dexmedetomidina; Fármacos Neuroprotetores; Complicações Cognitivas Pós-Operatórias; Animais; Disfunção Cognitiva/tratamento farmacológico; Disfunção Cognitiva/etiologia; Dexmedetomidina/farmacologia; Dexmedetomidina/uso terapêutico; Inflamassomos/metabolismo; Camundongos; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Fármacos Neuroprotetores/farmacologia; Fármacos Neuroprotetores/uso terapêutico; Transdução de Sinais

Palavras-chave

NLRP3 inflammasome; antioxidant; dexmedetomidine; inflammation; postoperative cognitive dysfunction; reactive oxygen species

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Neuroprotetores / Dexmedetomidina / Disfunção Cognitiva / Complicações Cognitivas Pós-Operatórias Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2022 Tipo de documento: Article

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