Long-Term Biodistribution and Safety of Human Dystrophin Expressing Chimeric Cell Therapy After Systemic-Intraosseous Administration to Duchenne Muscular Dystrophy Model.

Siemionow, Maria; Brodowska, Sonia; Langa, Paulina; Zalants, Kristina; Kozlowska, Katarzyna; Grau-Kazmierczak, Wictoria; Heydemann, Ahlke

Siemionow, Maria; Brodowska, Sonia; Langa, Paulina; Zalants, Kristina; Kozlowska, Katarzyna; Grau-Kazmierczak, Wictoria; Heydemann, Ahlke.

Afiliação

Siemionow M; Poznan University of Medical Sciences, Poznan, Poland. siemiom@uic.edu.
Brodowska S; Department of Orthopaedics, University of Illinois at Chicago, Molecular Biology Research Building, 900 S. Ashland Ave. Room# 3356, Chicago, IL, 60607, USA. siemiom@uic.edu.
Langa P; Department of Orthopaedics, University of Illinois at Chicago, Molecular Biology Research Building, 900 S. Ashland Ave. Room# 3356, Chicago, IL, 60607, USA.
Zalants K; Department of Orthopaedics, University of Illinois at Chicago, Molecular Biology Research Building, 900 S. Ashland Ave. Room# 3356, Chicago, IL, 60607, USA.
Kozlowska K; Department of Orthopaedics, University of Illinois at Chicago, Molecular Biology Research Building, 900 S. Ashland Ave. Room# 3356, Chicago, IL, 60607, USA.
Grau-Kazmierczak W; Poznan University of Medical Sciences, Poznan, Poland.
Heydemann A; Department of Orthopaedics, University of Illinois at Chicago, Molecular Biology Research Building, 900 S. Ashland Ave. Room# 3356, Chicago, IL, 60607, USA.

Arch Immunol Ther Exp (Warsz) ; 70(1): 20, 2022 Aug 17.

Article em En | MEDLINE | ID: mdl-35978142

Assuntos

Distrofia Muscular de Duchenne; Animais; Terapia Baseada em Transplante de Células e Tecidos; Distrofina/genética; Distrofina/metabolismo; Humanos; Camundongos; Camundongos Endogâmicos mdx; Músculo Esquelético; Distrofia Muscular de Duchenne/genética; Distrofia Muscular de Duchenne/metabolismo; Distrofia Muscular de Duchenne/terapia; Espectrina/metabolismo; Distribuição Tecidual

Palavras-chave

Advanced therapy medicinal product; Biodistribution; Duchenne muscular dystrophy; Dystrophin expressing chimeric cells; Systemic-intraosseous administration; Therapy safety

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Distrofia Muscular de Duchenne Limite: Animals / Humans Idioma: En Revista: Arch Immunol Ther Exp (Warsz) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Polônia

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