Structure-based design of anti-mycobacterial drug leads that target the mycolic acid transporter MmpL3.

Hu, Tianyu; Yang, Xiaolin; Liu, Fengjiang; Sun, Shan; Xiong, Zhiqi; Liang, Jingxi; Yang, Xiaobao; Wang, Haofeng; Yang, Xiuna; Guddat, Luke W; Yang, Haitao; Rao, Zihe; Zhang, Bing

Hu, Tianyu; Yang, Xiaolin; Liu, Fengjiang; Sun, Shan; Xiong, Zhiqi; Liang, Jingxi; Yang, Xiaobao; Wang, Haofeng; Yang, Xiuna; Guddat, Luke W; Yang, Haitao; Rao, Zihe; Zhang, Bing.

Afiliação

Hu T; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, C
Yang X; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Liu F; Innovative Center for Pathogen Research, Guangzhou Laboratory, Guangzhou 510005, China.
Sun S; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Xiong Z; Laboratory of Structural Biology, Tsinghua University, Beijing 100084, China.
Liang J; State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300353, China.
Yang X; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Wang H; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Yang X; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; Shanghai Clinical Research and Trial Center, Shanghai 201210, China.
Guddat LW; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
Yang H; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; Shanghai Clinical Research and Trial Center, Shanghai 201210, China. Electronic address: yanght@shanghaitech.edu.cn.
Rao Z; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; Innovative Center for Pathogen Research, Guangzhou Laboratory, Guangzhou 510005, China; Laboratory of Structural Biology, Tsinghua University, Beijing 10
Zhang B; Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; Shanghai Clinical Research and Trial Center, Shanghai 201210, China. Electronic address: zhangbing@shanghaitech.edu.cn.

Structure ; 30(10): 1395-1402.e4, 2022 10 06.

Article em En | MEDLINE | ID: mdl-35981536

Assuntos

Mycobacterium tuberculosis; Ácidos Micólicos; Antituberculosos/química; Antituberculosos/farmacologia; Antituberculosos/uso terapêutico; Proteínas de Bactérias/metabolismo; Microscopia Crioeletrônica; Humanos; Proteínas de Membrana/metabolismo; Proteínas de Membrana Transportadoras/metabolismo; Mycobacterium tuberculosis/metabolismo; Ácidos Micólicos/metabolismo; Prótons

Palavras-chave

MmpL3; Mtb; ST004; drug design; drug target; mycobacteria

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mycobacterium tuberculosis / Ácidos Micólicos Limite: Humans Idioma: En Revista: Structure Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Ano de publicação: 2022 Tipo de documento: Article

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