Histone deacetylase-10 liberates spermidine to support polyamine homeostasis and tumor cell growth.

Stewart, Tracy Murray; Foley, Jackson R; Holbert, Cassandra E; Klinke, Glynis; Poschet, Gernot; Steimbach, Raphael R; Miller, Aubry K; Casero, Robert A

Stewart, Tracy Murray; Foley, Jackson R; Holbert, Cassandra E; Klinke, Glynis; Poschet, Gernot; Steimbach, Raphael R; Miller, Aubry K; Casero, Robert A.

Afiliação

Stewart TM; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: tmurray2@jhmi.edu.
Foley JR; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Holbert CE; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Klinke G; Metabolomics Core Technology Platform, Center for Organismal Studies (COS), Heidelberg University, Heidelberg, Germany.
Poschet G; Metabolomics Core Technology Platform, Center for Organismal Studies (COS), Heidelberg University, Heidelberg, Germany.
Steimbach RR; Biosciences Faculty, Heidelberg University, Heidelberg, Germany; Cancer Drug Development, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Miller AK; Cancer Drug Development, German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany.
Casero RA; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: rcasero@jhmi.edu.

J Biol Chem ; 298(10): 102407, 2022 10.

Article em En | MEDLINE | ID: mdl-35988653

Assuntos

Inibidores de Histona Desacetilases; Neoplasias; Espermidina; Humanos; Proliferação de Células; Eflornitina/farmacologia; Histona Desacetilases/genética; Histona Desacetilases/metabolismo; Homeostase; Neoplasias/metabolismo; Neoplasias/patologia; Espermidina/antagonistas & inibidores; Espermidina/metabolismo; Inibidores de Histona Desacetilases/química; Inibidores de Histona Desacetilases/farmacologia

Palavras-chave

N8-acetylspermidine; colorectal cancer; difluoromethylornithine (DFMO); histone deacetylase-10 (HDAC10); metabolism; microbiome; polyamine; polyamine-blocking therapy; spermidine; tumor microenvironment (TME)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espermidina / Inibidores de Histona Desacetilases / Neoplasias Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2022 Tipo de documento: Article

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