Directing ricin-based immunotoxins with targeting affibodies and KDEL signal peptide to cancer cells effectively induces apoptosis and tumor suppression.

Park, Seong Guk; Kim, Heeyeon; Jun, Heejin; Choi, Sun Young; Kim, Eunhee; Kang, Sebyung

Park, Seong Guk; Kim, Heeyeon; Jun, Heejin; Choi, Sun Young; Kim, Eunhee; Kang, Sebyung.

Afiliação

Park SG; Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Korea.
Kim H; Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Korea.
Jun H; Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Korea.
Choi SY; Department of Medicine, Graduate School, Korea University, Seoul, Korea. csy4ycy2@gmail.com.
Kim E; Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Korea. ehkim@unist.ac.kr.
Kang S; Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Korea. sabsab7@unist.ac.kr.

J Nanobiotechnology ; 20(1): 387, 2022 Aug 23.

Article em En | MEDLINE | ID: mdl-35999603

Assuntos

Imunotoxinas; Neoplasias; Ricina; Animais; Apoptose; Endocitose; Imunotoxinas/metabolismo; Imunotoxinas/farmacologia; Camundongos; Neoplasias/tratamento farmacológico; Sinais Direcionadores de Proteínas; Ricina/farmacologia; Ricina/toxicidade

Palavras-chave

Affibody molecule; Drug delivery; Intracellular delivery; KDEL; Recombinant immunotoxin; Ricin; Tumor suppression

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ricina / Imunotoxinas / Neoplasias Limite: Animals Idioma: En Revista: J Nanobiotechnology Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google