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Evolution of SIVmac239 following serial passaging in humanized mice.
Curlin, James Z; Schmitt, Kimberly; Remling-Mulder, Leila; Morrison, Jared; Baczenas, John J; Tibbits, Corina Valencia; Goff, Kelly; O'Connor, Shelby; Stenglein, Mark; Marx, Preston; Akkina, Ramesh.
Afiliação
  • Curlin JZ; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
  • Schmitt K; ADEAR Training Program, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Remling-Mulder L; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
  • Morrison J; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
  • Baczenas JJ; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
  • Tibbits CV; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Goff K; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
  • O'Connor S; Department of Tropical Medicine, School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
  • Stenglein M; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Marx P; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
  • Akkina R; Department of Tropical Medicine, School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
J Med Primatol ; 51(5): 284-287, 2022 10.
Article em En | MEDLINE | ID: mdl-36030392
Serial passage of SIVmac239 allows for greater understanding of the genetic changes necessary for cross-species transmission of primate lentiviruses into humans. Using humanized mice, we show that adaptive mutations continue to accumulate in SIVmac239 during four serial passages, with persistent CD4+ T cell decline and increases in plasma viral loads.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças dos Roedores / Síndrome de Imunodeficiência Adquirida dos Símios / Vírus da Imunodeficiência Símia Limite: Animals / Humans Idioma: En Revista: J Med Primatol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças dos Roedores / Síndrome de Imunodeficiência Adquirida dos Símios / Vírus da Imunodeficiência Símia Limite: Animals / Humans Idioma: En Revista: J Med Primatol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos