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Challenges and Strategies for the Recruitment of Patients With Schizophrenia in a Research Setting.
Deckler, Elizabeth; Ferland, Melissa; Brazis, Stephanie; Mayer, Megan R; Carlson, Marlene; Kantrowitz, Joshua T.
Afiliação
  • Deckler E; Jackson Memorial Hospital, Miami, Florida, USA.
  • Ferland M; New York State Psychiatric Institute, New York, USA.
  • Brazis S; New York State Psychiatric Institute, New York, USA.
  • Mayer MR; New York State Psychiatric Institute, New York, USA.
  • Carlson M; New York State Psychiatric Institute, New York, USA.
  • Kantrowitz JT; Columbia University, College of Physicians and Surgeons, New York, New York, USA.
Int J Neuropsychopharmacol ; 25(11): 924-932, 2022 11 17.
Article em En | MEDLINE | ID: mdl-36037521
ABSTRACT

BACKGROUND:

With numerous potentially novel targets and pharmacodynamic biomarkers for schizophrenia entering late-stage testing, the next decade will bring an urgent need for well-conducted clinical trials. A critically important step for the successful execution of clinical research trials is timely and appropriate recruitment of participants. Patients with schizophrenia can be especially challenging to recruit because of the disability inherent in psychotic spectrum disorders. Research on how best to recruit for clinical trials is understudied. Clearly defining a model for recruitment procedures would be valuable for researchers and, by extension, the patient populations that may benefit from the insight gained by future clinical research.

METHODS:

This article aims to offer suggestions for recruitment based on years of experience at the Columbia Schizophrenia Research Clinic (CSRC), a hub for clinical trials focusing on the etiology and treatment of various psychotic disorders.

RESULTS:

The present report provides practical, step-by-step recommendations for implementing the highly effective CSRC recruitment model, including the benefits of 2 recruitment initiatives that were instituted in 2018 hiring a dedicated recruiter and targeted chart reviews at affiliated clinics. Other topics discussed include our umbrella protocol and database, advertising, and tips for collaborating with external sites.

CONCLUSIONS:

Despite ongoing complications from coronavirus disease 2019, these strategies have been successful, increasing the rate of both consents and study enrollments by approximately 40% and enabling the CSRC to conduct multiple studies simultaneously.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos / Esquizofrenia / COVID-19 Tipo de estudo: Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Int J Neuropsychopharmacol Assunto da revista: NEUROLOGIA / PSICOFARMACOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos / Esquizofrenia / COVID-19 Tipo de estudo: Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Int J Neuropsychopharmacol Assunto da revista: NEUROLOGIA / PSICOFARMACOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos