Z1456467176 alleviates gouty arthritis by allosterically modulating P2X7R to inhibit NLRP3 inflammasome activation.

Li, Xiaoling; Liu, Yiming; Luo, Chengyu; Tao, Jinhui

Li, Xiaoling; Liu, Yiming; Luo, Chengyu; Tao, Jinhui.

Afiliação

Li X; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Liu Y; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Luo C; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Tao J; Department of Rheumatology and Immunology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Front Pharmacol ; 13: 979939, 2022.

Article em En | MEDLINE | ID: mdl-36052144

Palavras-chave

P2X7 receptor; allosteric regulation; gout; interleukin-1beta; nod-like receptor protein 3

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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