Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria.
Malar J
; 21(1): 255, 2022 Sep 06.
Article
em En
| MEDLINE
| ID: mdl-36068577
ABSTRACT
BACKGROUND:
Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive function are increased in human experimental Plasmodium falciparum infection, but have not been studied in clinical malaria.METHODS:
Using flow-cytometry, circulating polymorphonuclear-MDSC were evaluated in cryopreserved samples from patients with uncomplicated Plasmodium vivax (n = 8) and uncomplicated (n = 4) and severe (n = 16) falciparum malaria from Papua, Indonesia.RESULTS:
The absolute number of circulating polymorphonuclear-MDSC were significantly elevated in severe falciparum malaria patients compared to controls (n = 10). Polymorphonuclear-MDSC levels in uncomplicated vivax malaria were also elevated to levels comparable to that seen in severe falciparum malaria.CONCLUSION:
Control of expansion of immunosuppressive MDSC may be important for development of effective immune responses in falciparum and vivax malaria.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Malária Vivax
/
Malária Falciparum
/
Células Supressoras Mieloides
/
Malária
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Malar J
Assunto da revista:
MEDICINA TROPICAL
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Indonésia