Mechanistic Approach for Protective Effect of ARA290, a Specific Ligand for the Erythropoietin/CD131 Heteroreceptor, against Cisplatin-Induced Nephrotoxicity, the Involvement of Apoptosis and Inflammation Pathways.

Ghassemi-Barghi, Nasrin; Ehsanfar, Zeynab; Mohammadrezakhani, Omid; Ashari, Sorour; Ghiabi, Shamim; Bayrami, Zahra

Ghassemi-Barghi, Nasrin; Ehsanfar, Zeynab; Mohammadrezakhani, Omid; Ashari, Sorour; Ghiabi, Shamim; Bayrami, Zahra.

Afiliação

Ghassemi-Barghi N; Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran. ngeternal67@yahoo.com.
Ehsanfar Z; Vidagen Pharmed Company, Tehran, Iran.
Mohammadrezakhani O; Student Research Committee, Ramsar Campus, Mazandaran University of Medical Sciences, Ramsar, Iran.
Ashari S; Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Ghiabi S; Department of Medical Chemistry, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Bayrami Z; Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Inflammation ; 46(1): 342-358, 2023 Feb.

Article em En | MEDLINE | ID: mdl-36085231

Assuntos

Cisplatino; Eritropoetina; Humanos; Cisplatino/toxicidade; Fator de Necrose Tumoral alfa/metabolismo; Antioxidantes/farmacologia; Caspase 3/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Proteína X Associada a bcl-2/metabolismo; Células HEK293; Interleucina-6/metabolismo; Ligantes; Eritropoetina/farmacologia; Eritropoetina/uso terapêutico; Estresse Oxidativo; Inflamação/induzido quimicamente; Inflamação/tratamento farmacológico; Inflamação/metabolismo; Apoptose; Rim/metabolismo

Palavras-chave

ARA290; cisplatin; comet assay.; genotoxicity; nephrotoxicity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Eritropoetina / Cisplatino Limite: Humans Idioma: En Revista: Inflammation Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Irã

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