Small animal photon counting cone-beam CT on a preclinical radiation research platform to improve radiation dose calculation accuracy.
Phys Med Biol
; 67(19)2022 09 26.
Article
em En
| MEDLINE
| ID: mdl-36096129
ABSTRACT
Objective.Cone beam CT (CBCT) in preclinical small animal irradiation platforms provides essential information for image guidance and radiation dose calculation for experiment planning. This project developed a photon-counting detector (PCD)-based multi(3)-energy (ME-)CBCT on a small animal irradiator to improve the accuracy of material differentiation and hence dose calculation, and compared to conventional flat panel detector (FPD)-based CBCT.Approach.We constructed a mechanical structure to mount a PCD to an existing preclinical irradiator platform and built a data acquisition pipeline to acquire x-ray projection data with a 100 kVp x-ray beam using three different energy thresholds in a single gantry rotation. We implemented an energy threshold optimization scheme to determine optimal thresholds to balance signal-to-noise ratios (SNRs) among energy channels. Pixel-based detector response calibration was performed to remove ring artifacts in reconstructed CBCT images. Feldkamp-Davis-Kress method was employed to reconstruct CBCT images and a total-variance regularization-based optimization model was used to decompose CBCT images into bone and water material images. We compared dose calculation results using PCD-based ME-CBCT with that of FPD-based CBCT.Main results.The optimal nominal energy thresholds were determined as 26, 56, and 90 keV, under which SNRs in a selected region-of-interest in the water region were 6.11, 5.91 and 5.93 in the three energy channels, respectively. Compared with dose calculation results using FPD-based CBCT, using PCD-based ME-CBCT reduced the mean relative error from 49.5% to 16.4% in bone regions and from 7.5% to 6.9% in soft tissue regions.Significance.PCD-based ME-CBCT is beneficial in improving radiation dose calculation accuracy in experiment planning of preclinical small animal irradiation researches.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tomografia Computadorizada por Raios X
/
Tomografia Computadorizada de Feixe Cônico
Limite:
Animals
Idioma:
En
Revista:
Phys Med Biol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos