The effects of astaxanthin supplementation on expression of microRNAs involved in cardiovascular diseases: a systematic review of current evidence.
Int J Food Sci Nutr
; 73(8): 1019-1029, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-36117431
ABSTRACT
MicroRNAs (miRNAs) have biological roles in controlling oxidative stress. Astaxanthin (AST) may regulate circulating miRNAs in cardiovascular diseases (CVDs); therefore, our study aimed to evaluate the effect of AST on miRNA involved in CVDs. A systematic literature search from inception to August 2022 resulted in 80 preliminary studies; 15 articles were included. In vitro studies indicated that AST up-regulated miRNAs compromised miR-138, miR-7, miR-29a-3p, and miR-200a, while down-regulated miR-382-5p, miR-31-5p, and miR-21. In vivo articles revealed that AST increased the expression of miR-124, miR-7, miR-29a-3p, and miR-200a but decreased miR-21 and miR-31-5p and the only clinical study showed a drop in miR-146a. The findings indicate that AST regulated different pathways of miRNAs implicated in various conditions. Therefore AST as a new therapeutic strategy could be essential in preventing and controlling CVDs. However, more studies, including clinical trials, are needed to determine the influence of AST on miRNAs associated with CVDs.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
MicroRNAs
Tipo de estudo:
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Int J Food Sci Nutr
Assunto da revista:
CIENCIAS DA NUTRICAO
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Irã