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Synergistic Sequential Emission of Fractional 10.600 and 1540 nm Lasers for Skin Resurfacing: An Ex Vivo Histological Evaluation.
Nisticò, Steven Paul; Bennardo, Luigi; Zingoni, Tiziano; Pieri, Laura; Fusco, Irene; Rossi, Francesca; Magni, Giada; Cannarozzo, Giovanni.
Afiliação
  • Nisticò SP; Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.
  • Bennardo L; Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.
  • Zingoni T; El.En. Group, 50041 Calenzano, Italy.
  • Pieri L; Lasers in Dermatology Unit, Department of Dermatology, University of Rome Tor Vergata, 00133 Rome, Italy.
  • Fusco I; El.En. Group, 50041 Calenzano, Italy.
  • Rossi F; Institute of Applied Physics "Nello Carrara", National Research Council (IFAC-CNR), Sesto Fiorentino, 50019 Florence, Italy.
  • Magni G; Institute of Applied Physics "Nello Carrara", National Research Council (IFAC-CNR), Sesto Fiorentino, 50019 Florence, Italy.
  • Cannarozzo G; Unit of Lasers in Dermatology, University of Roma, Tor Vergata, 00133 Rome, Italy.
Medicina (Kaunas) ; 58(9)2022 Sep 19.
Article em En | MEDLINE | ID: mdl-36143985
ABSTRACT

Background:

Fractional ablative and non-ablative lasers are useful treatments for skin rejuvenation. A procedure that provides the sequential application of fractional ablative followed by non-ablative laser treatment may reduce patients' downtime and deliver better cosmetic results than with either laser alone.

Objective:

The purpose of the current study was to demonstrate the ameliorative and therapeutic effects in skin remodeling of the synergistic use of the two laser wavelengths (fractional ablative CO2 and non-ablative 1540 nm) with three different types of pulse shapes, S-Pulse (SP), D-Pulse (DP) and H-Pulse (HP), through which the CO2 laser can emit, performing an ex vivo histological evaluation.

Methods:

In this prospective study, ex vivo sheep inner thigh skin was chosen due to its similarity to human skin tissue, and a histological evaluation was performed. Three irradiation conditions, using all of the three CO2 pulse shapes (alone or averaged), were investigated (1) 10.600 nm alone, the sequential irradiation of the two wavelengths in the same perfectly controlled energy pulses (DOT) for the entire scan area; ((2) 10.600 nm followed immediately by 1540 nm; and (3) 1540 nm followed immediately by 10.600 nm).

Results:

When comparing ablative to sequential irradiations, the synergy of the two wavelengths did not alter the typical ablative pulse shape of the 10.600 nm laser alone. With the same CO2 pulse shape, the lesion depth did not vary with the synergy of the two wavelengths, while thermal lesion width increased compared to CO2 alone. The ablation rate was achieved, while the total thermal lesion coverage in the scanning area of CO2 - 1540 lasers was greater than when using CO2 alone and then the other sequential irradiation.

Conclusions:

This study provides important preclinical data for new and early uses of the novel 10.600/1540 nm dual-wavelength non-ablative fractional laser. The synergy of the two wavelengths enhanced all the benefits already available when using CO2 laser systems both in terms of tone strengthening, thanks to a greater shrinking effect, and in terms of stimulation and collagen remodeling thanks to a greater volumetric thermal effect.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dióxido de Carbono / Lasers de Gás Tipo de estudo: Observational_studies Limite: Animals / Humans Idioma: En Revista: Medicina (Kaunas) Assunto da revista: MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dióxido de Carbono / Lasers de Gás Tipo de estudo: Observational_studies Limite: Animals / Humans Idioma: En Revista: Medicina (Kaunas) Assunto da revista: MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália