Copper-Catalyzed Carboxylation of Aryl Thianthrenium Salts with CO2.
Angew Chem Int Ed Engl
; 61(47): e202212975, 2022 Nov 21.
Article
em En
| MEDLINE
| ID: mdl-36195552
ABSTRACT
Carboxyl group is one of the most widely used groups in organic synthesis. Herein, an efficient copper-catalyzed carboxylation of aryl thianthrenium salts with carbon dioxide (CO2 ) at room temperature has been developed. The reaction employs low loading of cuprous chloride catalyst under 1â
atm CO2 and exhibits good functional group tolerance. In combination with C-H thianthrenation of aromatic hydrocarbons, this work provides an efficient method for the site-selective C-H carboxylation of aromatic hydrocarbons. It may serve as a significant late-stage carboxylation tool for the modification of drug molecules in the future.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China