Neuronal hyperexcitability and ion channel dysfunction in CDKL5-deficiency patient iPSC-derived cortical organoids.

Wu, Wei; Yao, Hang; Negraes, Priscilla D; Wang, Juan; Trujillo, Cleber A; de Souza, Janaina S; Muotri, Alysson R; Haddad, Gabriel G

Wu, Wei; Yao, Hang; Negraes, Priscilla D; Wang, Juan; Trujillo, Cleber A; de Souza, Janaina S; Muotri, Alysson R; Haddad, Gabriel G.

Afiliação

Wu W; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Yao H; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Negraes PD; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Wang J; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Trujillo CA; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA.
de Souza JS; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Muotri AR; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA; Department of Cellular & Molecular Medicine, Stem Cell Program, Center for Academic Research and Training in Anthropogeny (CARTA), Archealization Center (ArchC), Kavli Institute for Brain and
Haddad GG; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA; Department of Neurosciences, University of California San Diego School of Medicine, La Jolla, CA, USA; Rady Children's Hospital, San Diego, CA, USA. Electronic address: ghaddad@health.ucsd.edu.

Neurobiol Dis ; 174: 105882, 2022 Nov.

Article em En | MEDLINE | ID: mdl-36202289

Assuntos

Epilepsia; Células-Tronco Pluripotentes Induzidas; Síndrome de Rett; Humanos; Organoides; Canais Iônicos; Síndrome de Rett/genética; Epilepsia/genética; Proteínas Serina-Treonina Quinases/genética

Palavras-chave

AP firing; CDD; RTT; cortical organoid; ion channel; patch-clamp

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Rett / Epilepsia / Células-Tronco Pluripotentes Induzidas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google