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Uterine contractile activity in healthy women throughout the menstrual cycle measured using a novel quantitative two-dimensional transvaginal ultrasound speckle tracking method.
Rees, Connie Odette; de Boer, Anna; Huang, Yizhou; Wessels, Blijke; Blank, Celine; Kuijsters, Nienke; Huppelschoten, Aleida; Zizolfi, Brunella; Foreste, Virginia; Di Spiezio Sardo, Attilio; Christoforidis, Nikos; van Vliet, Hubertus; Mischi, Massimo; Schoot, Benedictus Christiaan.
Afiliação
  • Rees CO; Department of Obstetrics and Gynaecology, Catharina Hospital, Eindhoven, the Netherlands; Laboratory of Biomedical Diagnostics, Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands; Department of Reproductive Medicine, Ghent University Hospital, Ghent,
  • de Boer A; Department of Obstetrics and Gynaecology, Catharina Hospital, Eindhoven, the Netherlands.
  • Huang Y; Laboratory of Biomedical Diagnostics, Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
  • Wessels B; Laboratory of Biomedical Diagnostics, Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
  • Blank C; Laboratory of Biomedical Diagnostics, Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands; Department of Reproductive Medicine, Ghent University Hospital, Ghent, Belgium.
  • Kuijsters N; Laboratory of Biomedical Diagnostics, Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
  • Huppelschoten A; Department of Obstetrics and Gynaecology, Catharina Hospital, Eindhoven, the Netherlands.
  • Zizolfi B; Department of Public Health - School of Medicine, University Federico II, Naples, Italy.
  • Foreste V; Department of Public Health - School of Medicine, University Federico II, Naples, Italy.
  • Di Spiezio Sardo A; Department of Public Health - School of Medicine, University Federico II, Naples, Italy.
  • Christoforidis N; Embryolab Fertility Center Thessaloniki, Greece.
  • van Vliet H; Department of Obstetrics and Gynaecology, Catharina Hospital, Eindhoven, the Netherlands; Department of Reproductive Medicine, Ghent University Hospital, Ghent, Belgium.
  • Mischi M; Laboratory of Biomedical Diagnostics, Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
  • Schoot BC; Department of Obstetrics and Gynaecology, Catharina Hospital, Eindhoven, the Netherlands; Laboratory of Biomedical Diagnostics, Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands; Department of Reproductive Medicine, Ghent University Hospital, Ghent,
Reprod Biomed Online ; 46(1): 115-122, 2023 01.
Article em En | MEDLINE | ID: mdl-36244894
ABSTRACT
RESEARCH QUESTION To explore normal uterine contractile function across the menstrual cycle using a novel quantitative ultrasound method.

DESIGN:

This multicentre prospective observational study took place in three European centres from 2014 to 2022. Uterine contraction frequency (contractions/minute), amplitude, direction (cervix-to-fundus, C2F; fundus-to-cervix; F2C), velocity and coordination were investigated. Features were extracted from transvaginal ultrasound recordings (TVUS) using speckle tracking. Premenopausal women ≥18 years of age, with normal, natural menstrual cycles were included. A normal cycle was defined as regular (duration 28 ± 2 days), no dysmenorrhoea, no menometrorrhagia. Four-minute TVUS were performed during the menstrual phase, mid-follicular, late follicular phase, early luteal phase and/or late luteal phase. Of the 96 recordings available from 64 women, 70 were suitable for inclusion in the analysis.

RESULTS:

Contraction frequency (for the posterior wall) and velocity (for the anterior uterine wall in the F2C direction) were highest in the late follicular phase and lowest in the menstrual and late luteal phases (1.61 versus 1.31 and 1.35 contractions/min, P < 0.001 and 0.81 versus 0.67 and 0.62 mm/s, P < 0.001, respectively). No significant difference was found for contraction amplitude. Contraction coordination (simultaneous contraction of the anterior and posterior walls in the same direction) was least coordinated in the mid-follicular phase (P = 0.002).

CONCLUSIONS:

This is the first study to objectively measure uterine contraction features in healthy women during the natural menstrual cycle on TVUS. Likewise, it introduces contraction coordination as a specific feature of uterine peristalsis. Differences in uterine contractility across the menstrual cycle are confirmed, with highest activity seen in the late follicular phase, and lowest in the late luteal phase.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fase Folicular / Ciclo Menstrual Tipo de estudo: Observational_studies Limite: Female / Humans / Pregnancy Idioma: En Revista: Reprod Biomed Online Assunto da revista: MEDICINA REPRODUTIVA Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fase Folicular / Ciclo Menstrual Tipo de estudo: Observational_studies Limite: Female / Humans / Pregnancy Idioma: En Revista: Reprod Biomed Online Assunto da revista: MEDICINA REPRODUTIVA Ano de publicação: 2023 Tipo de documento: Article