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Tislelizumab-related enteritis successfully treated with adalimumab: A case report.
Chen, Na; Qian, Min-Jia; Zhang, Ru-Hui; Gao, Qi-Qi; He, Chao-Chao; Yao, Ya-Ke; Zhou, Jian-Ying; Zhou, Hua.
Afiliação
  • Chen N; Department of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China.
  • Qian MJ; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China.
  • Zhang RH; Department of Critical Care Medicine, Zhuji People's Hospital, Shaoxing 311800, Zhejiang Province, China.
  • Gao QQ; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China.
  • He CC; Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China.
  • Yao YK; Department of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China.
  • Zhou JY; Department of Pharmacy, Yiwu Central Hospital, Jinhua 322000, Zhejiang Province, China.
  • Zhou H; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China.
World J Clin Cases ; 10(28): 10186-10192, 2022 Oct 06.
Article em En | MEDLINE | ID: mdl-36246838
ABSTRACT

BACKGROUND:

With programmed death-1 (PD-1) inhibitors becoming the standard treatment for lung cancer, PD-1-related adverse reactions and treatment have gradually become prominent. CASE

SUMMARY:

First reported case of tislelizumab-related enteritis successfully treated with adalimumab 40mg every 2 wk for 3 times in an advanced lung cancer patient who received first-line tislelizumab/pemetrexed/carboplatin for 4 cycles. The patient continued receiving the treatment of pemetrexed/carboplatin after symptoms, abdominal computed tomography and colonoscopy improved, significant diarrhea was not occurred.

CONCLUSION:

Adalimumab can be an effective treatment option for patients with PD-1 antibody related enteritis if they do not respond well to glucocorticoid treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: World J Clin Cases Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: World J Clin Cases Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China