3-Silyl-3-Borylhex-4-Enoate: A Chiral Reagent for Asymmetric Crotylboration of Aldehydes.
Org Lett
; 24(42): 7822-7827, 2022 Oct 28.
Article
em En
| MEDLINE
| ID: mdl-36250588
ABSTRACT
A nonracemic 3-silyl-3-borylhex-4-enoate reagent has been developed. Its asymmetric crotylboration of aldehydes provides Z-anti-homoallylic alcohols possessing a trisubstituted vinylsilane in high yields with excellent stereo- and enantioselectivity. Diverse decoration of vinylsilane and ester groups, as well as formation of functionalized THF rings, showcase the potential of the approach in the synthesis of polyketide natural products.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Silanos
/
Aldeídos
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2022
Tipo de documento:
Article