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Intradermal vaccination of HPV-16 E6 synthetic peptides conjugated to an optimized Toll-like receptor 2 ligand shows safety and potent T cell immunogenicity in patients with HPV-16 positive (pre-)malignant lesions.
Speetjens, Frank M; Welters, Marij J P; Slingerland, Marije; van Poelgeest, Mariette I E; de Vos van Steenwijk, Peggy J; Roozen, Inge; Boekestijn, Sanne; Loof, Nikki M; Zom, Gijs G; Valentijn, A Rob P M; Krebber, Willem-Jan; Meeuwenoord, Nico J; Janssen, Catharina A H; Melief, Cornelis J M; van der Marel, Gijs A; Filippov, Dmitri V; van der Burg, Sjoerd H; Gelderblom, Hans; Ossendorp, Ferry.
Afiliação
  • Speetjens FM; Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
  • Welters MJP; Department of Medical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
  • Slingerland M; Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
  • van Poelgeest MIE; Department of Gynaecology, Leiden University Medical Center, Leiden, The Netherlands.
  • de Vos van Steenwijk PJ; Department of Obstetrics and Gynecology, Maastricht University Medical Centre, Maastricht, The Netherlands.
  • Roozen I; Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
  • Boekestijn S; Department of Medical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
  • Loof NM; Department of Medical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
  • Zom GG; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands.
  • Valentijn ARPM; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.
  • Krebber WJ; ISA Pharmaceuticals B.V, Oegstgeest, The Netherlands.
  • Meeuwenoord NJ; Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
  • Janssen CAH; Department of Gynaecology, Groene Hart Ziekenhuis, Gouda, The Netherlands.
  • Melief CJM; ISA Pharmaceuticals B.V, Oegstgeest, The Netherlands.
  • van der Marel GA; Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
  • Filippov DV; Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
  • van der Burg SH; Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
  • Gelderblom H; Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
  • Ossendorp F; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands F.A.Ossendorp@lumc.nl.
J Immunother Cancer ; 10(10)2022 10.
Article em En | MEDLINE | ID: mdl-36261215
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / Infecções por Papillomavirus / Papillomavirus Humano 16 / Vacinas contra Papillomavirus Tipo de estudo: Etiology_studies Limite: Female / Humans Idioma: En Revista: J Immunother Cancer Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Holanda
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / Infecções por Papillomavirus / Papillomavirus Humano 16 / Vacinas contra Papillomavirus Tipo de estudo: Etiology_studies Limite: Female / Humans Idioma: En Revista: J Immunother Cancer Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Holanda