TAS2940, a novel brain-penetrable pan-ERBB inhibitor, for tumors with HER2 and EGFR aberrations.

Oguchi, Kei; Araki, Hikari; Tsuji, Shingo; Nakamura, Masayuki; Miura, Akihiro; Funabashi, Kaoru; Osada, Akiko; Tanaka, Sakiho; Suzuki, Takamasa; Kobayashi, Susumu S; Mizuarai, Shinji

Oguchi, Kei; Araki, Hikari; Tsuji, Shingo; Nakamura, Masayuki; Miura, Akihiro; Funabashi, Kaoru; Osada, Akiko; Tanaka, Sakiho; Suzuki, Takamasa; Kobayashi, Susumu S; Mizuarai, Shinji.

Afiliação

Oguchi K; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd, Tsukuba, Japan.
Araki H; Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.
Tsuji S; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd, Tsukuba, Japan.
Nakamura M; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd, Tsukuba, Japan.
Miura A; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd, Tsukuba, Japan.
Funabashi K; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd, Tsukuba, Japan.
Osada A; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd, Tsukuba, Japan.
Tanaka S; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd, Tsukuba, Japan.
Suzuki T; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd, Tsukuba, Japan.
Kobayashi SS; Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd, Tsukuba, Japan.
Mizuarai S; Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.

Cancer Sci ; 114(2): 654-664, 2023 Feb.

Article em En | MEDLINE | ID: mdl-36282234

Assuntos

Antineoplásicos; Neoplasias Encefálicas; Glioblastoma; Neoplasias Pulmonares; Humanos; Camundongos; Animais; Antineoplásicos/farmacologia; Glioblastoma/tratamento farmacológico; Glioblastoma/genética; Receptor ErbB-2/metabolismo; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patologia; Encéfalo/patologia; Neoplasias Encefálicas/tratamento farmacológico; Neoplasias Encefálicas/genética; Linhagem Celular Tumoral; Ensaios Antitumorais Modelo de Xenoenxerto; Receptores ErbB/genética; Receptores ErbB/metabolismo

Palavras-chave

EGFR; HER2; TAS2940; brain penetration; exon 20 insertion

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma / Neoplasias Pulmonares / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cancer Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão

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