Discovery of novel DNA-damaging agents through phenotypic screening for DNA double-strand break.

Zhang, Doudou; Shimokawa, Takashi; Guo, Qianqian; Dan, Shingo; Miki, Yoshio; Sunada, Shigeaki

Zhang, Doudou; Shimokawa, Takashi; Guo, Qianqian; Dan, Shingo; Miki, Yoshio; Sunada, Shigeaki.

Afiliação

Zhang D; Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Shimokawa T; Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
Guo Q; Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Dan S; Department of Oncology, Juntendo University School of Medicine, Tokyo, Japan.
Miki Y; Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
Sunada S; Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

Cancer Sci ; 114(3): 1108-1117, 2023 Mar.

Article em En | MEDLINE | ID: mdl-36385507

Assuntos

Antineoplásicos; Quebras de DNA de Cadeia Dupla; Humanos; Histonas/metabolismo; Etoposídeo/farmacologia; Reparo do DNA; Dano ao DNA; DNA

Palavras-chave

DNA double-strand break; bioinformatics; drug screening; topoisomerase II inhibitor; Î³H2AX

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quebras de DNA de Cadeia Dupla / Antineoplásicos Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Humans Idioma: En Revista: Cancer Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão

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