Your browser doesn't support javascript.
loading
Generation of cytochrome P450 enzyme-polymorphic human induced pluripotent stem cell lines with CYP2D6*10/CYP3A5*3C and CYP2D6*10/CYP2C19*2.
Lee, Jaehun; Kim, Gyeongmin; Chi, Kyun Yoo; Han, Choongseong; Kim, Jong-Hoon.
Afiliação
  • Lee J; Laboratory of Stem Cells and Tissue Regeneration, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, South Korea; Department of New Drug Development, NEXEL Co., Ltd., Seoul 02580, South Korea.
  • Kim G; Laboratory of Stem Cells and Tissue Regeneration, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, South Korea.
  • Chi KY; Laboratory of Stem Cells and Tissue Regeneration, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, South Korea.
  • Han C; Department of New Drug Development, NEXEL Co., Ltd., Seoul 02580, South Korea.
  • Kim JH; Laboratory of Stem Cells and Tissue Regeneration, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, South Korea. Electronic address: jhkim@korea.ac.kr.
Stem Cell Res ; 65: 102970, 2022 12.
Article em En | MEDLINE | ID: mdl-36399926
ABSTRACT
Cytochrome P450 (CYP) reaction phenotyping has become crucial for predicting drug reactions and side effects. Single nucleotide polymorphisms (SNPs) in CYP genes alter drug metabolism capacity and cause unexpected drug-related reactions. Here, we established two human induced pluripotent stem cell (hiPSC) lines with pharmacologically important SNPs in CYP2D6 in conjunction with CYP2C19 or CYP3A5 genes. These hiPSC lines can serve as valuable resources for expanding our understanding of the relationships between genotypes and drug reactions.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Citocromo P-450 CYP2D6 / Citocromo P-450 CYP3A / Células-Tronco Pluripotentes Induzidas / Citocromo P-450 CYP2C19 Limite: Humans Idioma: En Revista: Stem Cell Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Coréia do Sul
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Citocromo P-450 CYP2D6 / Citocromo P-450 CYP3A / Células-Tronco Pluripotentes Induzidas / Citocromo P-450 CYP2C19 Limite: Humans Idioma: En Revista: Stem Cell Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Coréia do Sul