Risk of CKD Following Detection of Microscopic Hematuria: A Retrospective Cohort Study.
Am J Kidney Dis
; 81(4): 425-433.e1, 2023 04.
Article
em En
| MEDLINE
| ID: mdl-36400245
ABSTRACT
RATIONALE & OBJECTIVE:
Microscopic hematuria is an uncertain risk factor for chronic kidney disease (CKD). We investigated the association between persistent or single episodes of microscopic hematuria and the development of incident CKD, overall and separately among men and women. STUDYDESIGN:
Retrospective cohort study. SETTING &PARTICIPANTS:
A total of 232,220 Korean adults without CKD at baseline who underwent repeated regular health examinations at Kangbuk Samsung Health Study formed the study cohort. EXPOSURE Microscopic hematuria was defined by≥5 red blood cells per high-power field. Participants were categorized into 1 of 4 groups according to the presence of hematuria at 2 consecutive examinations (1) no hematuria at both examinations (reference group); (2) hematuria followed by no hematuria (regressed hematuria group); (3) no hematuria followed by hematuria (developed hematuria group); and (4) hematuria at both examinations (persistent hematuria group).OUTCOME:
CKD was defined as an estimated glomerular filtration rate<60mL/min/1.73m2 or proteinuria (1+or more on dipstick examination). ANALYTICALAPPROACH:
Semiparametric proportional hazards models were used to estimate hazard ratios.RESULTS:
During a 4.8-year median follow-up period, 2,392 participants developed CKD. Multivariable-adjusted hazard ratios for incident CKD, comparing the regressed, developed, and persistent hematuria groups to the no-hematuria group were 1.85 (95% CI, 1.35-2.53), 3.18 (95% CI, 2.54-3.98), and 5.23 (95% CI, 4.15-6.59), respectively. The association between persistent hematuria and incident CKD was stronger in men than women (P for interaction<0.001), although a statistically significant association was observed in both sexes.LIMITATIONS:
Lack of albuminuria and inability to consider specific glomerular diseases.CONCLUSIONS:
Men and women with microscopic hematuria, especially persistent hematuria, may be at increased risk of CKD.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Insuficiência Renal Crônica
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Am J Kidney Dis
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Coréia do Sul