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Systematic pharmacological analysis of agonistic and antagonistic fibroblast growth factor receptor 1 MAbs reveals a similar unique mode of action.
Chan, Jocelyn; Chan, Joyce; Shao, Lily; Stawicki, Scott S; Pham, Victoria C; Akita, Rob W; Hafner, Marc; Crocker, Lisa; Yu, Kebing; Koerber, James T; Schaefer, Gabriele; Comps-Agrar, Laetitia.
Afiliação
  • Chan J; Department of Molecular Oncology, Genentech Inc, South San Francisco, California, USA.
  • Chan J; Department of Biochemical and Cellular Pharmacology, Genentech Inc, South San Francisco, USA.
  • Shao L; Department of Molecular Oncology, Genentech Inc, South San Francisco, California, USA.
  • Stawicki SS; Department of Antibody Engineering, Genentech Inc, South San Francisco, California, USA.
  • Pham VC; Department of Microchemistry, Proteomics, Lipidomics and NGS, Genentech Inc, South San Francisco, California, USA.
  • Akita RW; Department of Molecular Oncology, Genentech Inc, South San Francisco, California, USA.
  • Hafner M; Department of Oncology Bioinformatics, Genentech Inc, South San Francisco, California, USA.
  • Crocker L; Department of Translational Oncology, Genentech Inc, South San Francisco, California, USA.
  • Yu K; Department of Microchemistry, Proteomics, Lipidomics and NGS, Genentech Inc, South San Francisco, California, USA.
  • Koerber JT; Department of Antibody Engineering, Genentech Inc, South San Francisco, California, USA.
  • Schaefer G; Department of Molecular Oncology, Genentech Inc, South San Francisco, California, USA. Electronic address: schaefer.gabriele@gene.com.
  • Comps-Agrar L; Department of Biochemical and Cellular Pharmacology, Genentech Inc, South San Francisco, USA. Electronic address: compsagl@gene.com.
J Biol Chem ; 299(1): 102729, 2023 01.
Article em En | MEDLINE | ID: mdl-36410439
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Receptor Tipo 1 de Fator de Crescimento de Fibroblastos / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Receptor Tipo 1 de Fator de Crescimento de Fibroblastos / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos