Predicting transporter mediated drug-drug interactions via static and dynamic physiologically based pharmacokinetic modeling: A comprehensive insight on where we are now and the way forward.

Vijaywargi, Gautam; Kollipara, Sivacharan; Ahmed, Tausif; Chachad, Siddharth

Vijaywargi, Gautam; Kollipara, Sivacharan; Ahmed, Tausif; Chachad, Siddharth.

Afiliação

Vijaywargi G; Biopharmaceutics Group, Global Clinical Management, Dr. Reddy's Laboratories Ltd., Integrated Product Development Organization (IPDO), Hyderabad, Telangana, India.
Kollipara S; Biopharmaceutics Group, Global Clinical Management, Dr. Reddy's Laboratories Ltd., Integrated Product Development Organization (IPDO), Hyderabad, Telangana, India.
Ahmed T; Biopharmaceutics Group, Global Clinical Management, Dr. Reddy's Laboratories Ltd., Integrated Product Development Organization (IPDO), Hyderabad, Telangana, India.
Chachad S; Biopharmaceutics Group, Global Clinical Management, Dr. Reddy's Laboratories Ltd., Integrated Product Development Organization (IPDO), Hyderabad, Telangana, India.

Biopharm Drug Dispos ; 44(3): 195-220, 2023 Jun.

Article em En | MEDLINE | ID: mdl-36413625

Assuntos

Proteínas de Membrana Transportadoras; Modelos Biológicos; Humanos; Criança; Interações Medicamentosas; Proteínas de Membrana Transportadoras/metabolismo; Fígado/metabolismo

Palavras-chave

IVIVE; PBPK modeling; regulatory; special population; transporter-mediated drug-drug interactions

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Modelos Biológicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Revista: Biopharm Drug Dispos Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Índia

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