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Host-guest synergistic enhancement of antibacterial effect by a supramolecular strategy.
Ma, Mengke; Chen, Junyi; Zhang, Yahan; Du, Xinbei; Chen, Longming; Yu, Xiang; Zhou, Zhengui; Liu, Yang; Meng, Qingbin.
Afiliação
  • Ma M; Key Laboratory of Structure-Based Drug Design & Discovery of the Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China. y.liu@syphu.edu.cn.
  • Chen J; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P. R. China. nankaimqb@sina.com.
  • Zhang Y; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P. R. China. nankaimqb@sina.com.
  • Du X; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P. R. China. nankaimqb@sina.com.
  • Chen L; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P. R. China. nankaimqb@sina.com.
  • Yu X; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P. R. China. nankaimqb@sina.com.
  • Zhou Z; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P. R. China. nankaimqb@sina.com.
  • Liu Y; Gongan County People's Hospital, Jingzhou 434399, P. R. China. zzg750@126.com.
  • Meng Q; Key Laboratory of Structure-Based Drug Design & Discovery of the Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China. y.liu@syphu.edu.cn.
Org Biomol Chem ; 20(48): 9625-9628, 2022 12 14.
Article em En | MEDLINE | ID: mdl-36421981
ABSTRACT
A supramolecular synergistic antibacterial strategy involving direct complexation of a commercial antibacterial agent, azelaic acid (AzA) by a cationic pillar[5]arene (WP5A) is described. The formation of AzA/WP5A complex could exert synergistic antibacterial effect, leading to promote wound healing efficacy and reduce bacterial burden on S. aureus-infected mice models.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Staphylococcus aureus / Antibacterianos Limite: Animals Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Staphylococcus aureus / Antibacterianos Limite: Animals Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article