Your browser doesn't support javascript.
loading
CSF tau microtubule-binding region identifies pathological changes in primary tauopathies.
Horie, Kanta; Barthélemy, Nicolas R; Spina, Salvatore; VandeVrede, Lawren; He, Yingxin; Paterson, Ross W; Wright, Brenton A; Day, Gregory S; Davis, Albert A; Karch, Celeste M; Seeley, William W; Perrin, Richard J; Koppisetti, Rama K; Shaikh, Faris; Lago, Argentina Lario; Heuer, Hilary W; Ghoshal, Nupur; Gabelle, Audrey; Miller, Bruce L; Boxer, Adam L; Bateman, Randall J; Sato, Chihiro.
Afiliação
  • Horie K; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
  • Barthélemy NR; The Tracy Family Stable Isotope Labeling Quantitation Center, Washington University School of Medicine, St. Louis, MO, USA.
  • Spina S; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
  • VandeVrede L; The Tracy Family Stable Isotope Labeling Quantitation Center, Washington University School of Medicine, St. Louis, MO, USA.
  • He Y; Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Paterson RW; Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Wright BA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
  • Day GS; The Tracy Family Stable Isotope Labeling Quantitation Center, Washington University School of Medicine, St. Louis, MO, USA.
  • Davis AA; Department of Neurology, University College London Queen Square Institute of Neurology, University College London, London, UK.
  • Karch CM; Department of Neurosciences, University of California San Diego School of Medicine, La Jolla, CA, USA.
  • Seeley WW; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA.
  • Perrin RJ; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
  • Koppisetti RK; Hope Center for Neurological Disorders, St. Louis, MO, USA.
  • Shaikh F; Hope Center for Neurological Disorders, St. Louis, MO, USA.
  • Lago AL; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
  • Heuer HW; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
  • Ghoshal N; Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Gabelle A; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
  • Miller BL; Hope Center for Neurological Disorders, St. Louis, MO, USA.
  • Boxer AL; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
  • Bateman RJ; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
  • Sato C; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Nat Med ; 28(12): 2547-2554, 2022 12.
Article em En | MEDLINE | ID: mdl-36424467
ABSTRACT
Despite recent advances in fluid biomarker research in Alzheimer's disease (AD), there are no fluid biomarkers or imaging tracers with utility for diagnosis and/or theragnosis available for other tauopathies. Using immunoprecipitation and mass spectrometry, we show that 4 repeat (4R) isoform-specific tau species from microtubule-binding region (MTBR-tau275 and MTBR-tau282) increase in the brains of corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), frontotemporal lobar degeneration (FTLD)-MAPT and AD but decrease inversely in the cerebrospinal fluid (CSF) of CBD, FTLD-MAPT and AD compared to control and other FTLD-tau (for example, Pick's disease). CSF MTBR-tau measures are reproducible in repeated lumbar punctures and can be used to distinguish CBD from control (receiver operating characteristic area under the curve (AUC) = 0.889) and other FTLD-tau, such as PSP (AUC = 0.886). CSF MTBR-tau275 and MTBR-tau282 may represent the first affirmative biomarkers to aid in the diagnosis of primary tauopathies and facilitate clinical trial designs.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tauopatias / Degeneração Lobar Frontotemporal / Demência Frontotemporal / Doença de Alzheimer Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Humans Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tauopatias / Degeneração Lobar Frontotemporal / Demência Frontotemporal / Doença de Alzheimer Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Humans Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos