Xenopus GLP-1-based glycopeptides as dual glucagon-like peptide 1 receptor/glucagon receptor agonists with improved in vivo stability for treating diabetes and obesity.

Li, Qiang; Yang, Qimeng; Han, Jing; Liu, Xiaohan; Fu, Junjie; Yin, Jian

Li, Qiang; Yang, Qimeng; Han, Jing; Liu, Xiaohan; Fu, Junjie; Yin, Jian.

Afiliação

Li Q; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China.
Yang Q; School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou 221116, China.
Han J; School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou 221116, China; Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Ministry of Education, Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Guangxi M
Liu X; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China.
Fu J; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China. Electronic address: jfu@jiangnan.edu.cn.
Yin J; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China. Electronic address: jianyin@jiangnan.edu.cn.

Chin J Nat Med ; 20(11): 863-872, 2022 Nov.

Article em En | MEDLINE | ID: mdl-36427920

Assuntos

Diabetes Mellitus Tipo 2; Peptídeo 1 Semelhante ao Glucagon; Camundongos; Animais; Peptídeo 1 Semelhante ao Glucagon/agonistas; Peptídeo 1 Semelhante ao Glucagon/metabolismo; Receptores de Glucagon/agonistas; Receptores de Glucagon/uso terapêutico; Xenopus laevis/metabolismo; Diabetes Mellitus Tipo 2/tratamento farmacológico; Glicopeptídeos/uso terapêutico; Obesidade/tratamento farmacológico; Hipoglicemiantes/farmacologia; Peptídeos/farmacologia

Palavras-chave

Diabetes; Glucagon; Glucagon-like peptide-1; O-GlcNAcylation; Obesity

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Peptídeo 1 Semelhante ao Glucagon Limite: Animals Idioma: En Revista: Chin J Nat Med Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google