A case of congenital multiple epiphyseal dysplasia from the Late Migration Period graveyard in Drnholec (Czech Republic).
Int J Paleopathol
; 40: 33-40, 2023 03.
Article
em En
| MEDLINE
| ID: mdl-36455429
ABSTRACT
OBJECTIVE:
To contribute to differential diagnosis of multiple epiphyseal dysplasia (MED) in archeological and clinical contexts. MATERIALS A skeleton of a 30- to 45-year-old male (grave no. 806) from the Late Migration Period graveyard in Drnholec-Pod sýpkou (Czech Republic), radio-carbon dated to AD 492-530.METHODS:
Morphological and metric analyses.RESULTS:
Significant pathological changes were noted on ossa coxae and proximal ends of the femora, which appear similar to changes associated with Legg-Calvé-Perthes disease. X-ray examination made it possible to rule out pseudoachondroplasia, rickets and metabolic bone diseases.CONCLUSIONS:
The finding was evaluated as a probable case of congenital multiple epiphyseal dysplasia.SIGNIFICANCE:
This case will contribute to the construction of estimates of the occurrence of this disease in historical populations and can be instructive for diagnostics in current medical practice.LIMITATIONS:
The final diagnosis is limited by the lack of genetic analysis. SUGGESTION FOR THE FUTURE RESEARCH Further clarification leading to diagnosis will benefit from genetic analysis and evaluation of skeletal remains throughout Europe.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteocondrodisplasias
/
Acondroplasia
/
Doença de Legg-Calve-Perthes
Limite:
Adult
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Int J Paleopathol
Ano de publicação:
2023
Tipo de documento:
Article