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Proteins in Tumor-Derived Plasma Extracellular Vesicles Indicate Tumor Origin.
Barlin, Meltem; Erdmann-Gilmore, Petra; Mudd, Jacqueline L; Zhang, Qiang; Seymour, Robert W; Guo, Zhanfang; Miessner, Julia R; Goedegebuure, S Peter; Bi, Ye; Osorio, Omar A; Alexander-Brett, Jennifer; Li, Shunqiang; Ma, Cynthia X; Fields, Ryan C; Townsend, R Reid; Held, Jason M.
Afiliação
  • Barlin M; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
  • Erdmann-Gilmore P; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
  • Mudd JL; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Department of Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
  • Zhang Q; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
  • Seymour RW; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
  • Guo Z; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
  • Miessner JR; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Department of Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
  • Goedegebuure SP; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Department of Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
  • Bi Y; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Department of Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
  • Osorio OA; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
  • Alexander-Brett J; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Department of Pathology and Immunology, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
  • Li S; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
  • Ma CX; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
  • Fields RC; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Department of Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
  • Townsend RR; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA.
  • Held JM; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri, USA; Department of Anesthesiology, Washington University School of Medicine in St Louis, St Louis, M
Mol Cell Proteomics ; 22(1): 100476, 2023 Jan.
Article em En | MEDLINE | ID: mdl-36470535
Cancer-derived extracellular vesicles (EVs) promote tumorigenesis, premetastatic niche formation, and metastasis via their protein cargo. However, the proteins packaged by patient tumors into EVs cannot be determined in vivo because of the presence of EVs derived from other tissues. We therefore developed a cross-species proteomic method to quantify the human tumor-derived proteome of plasma EVs produced by patient-derived xenografts of four cancer types. Proteomic profiling revealed individualized packaging of novel protein cargo, and machine learning accurately classified the type of the underlying tumor.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vesículas Extracelulares / Neoplasias Limite: Humans Idioma: En Revista: Mol Cell Proteomics Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vesículas Extracelulares / Neoplasias Limite: Humans Idioma: En Revista: Mol Cell Proteomics Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos