Gastrointestinal histopathology of acute colchicine toxicity after lower dose treatment of pericarditis: A case report.
Int J Crit Illn Inj Sci
; 12(3): 174-176, 2022.
Article
em En
| MEDLINE
| ID: mdl-36506926
ABSTRACT
Colchicine is an anti-inflammatory alkaloid drug with anti-microtubule activity. Colchicine toxicity is a serious and potentially fatal complication associated with hallmark histopathological features most conspicuous in proliferative tissues such as the gastrointestinal tract. These features have only been reported in patients treated with high doses. We report a patient who experienced acute colchicine toxicity with gastrointestinal histologic changes after treatment with the lowest dose of colchicine. Knowledge of drug-drug interactions and the organs involved in colchicine metabolism is imperative when using colchicine, even when administered at its lowest dose.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Int J Crit Illn Inj Sci
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos