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The Association Between Quadriceps Strength and Synovitis in Knee Osteoarthritis: An Exploratory Study From the Osteoarthritis Initiative.
Gong, Ze; Li, Shengfa; Cao, Peihua; Ruan, Guangfeng; Zhang, Yan; Zeng, Qing; He, Zijun; Li, Shilin; Chen, Rong; Zheng, Peng; Fan, Tao; Lu, Pengcheng; Zhao, Yijin; Englund, Martin; Madry, Henning; Huang, Guozhi; Li, Le; Li, Jia; Ding, Changhai.
Afiliação
  • Gong Z; Z. Gong, BS, L. Li, PhD, Institute of Medical Research, Northwestern Polytechnical University, Xi'an, China.
  • Li S; S. Li, PhD, P. Cao, PhD, G. Ruan, PhD, Y. Zhang, PhD, Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
  • Cao P; S. Li, PhD, P. Cao, PhD, G. Ruan, PhD, Y. Zhang, PhD, Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
  • Ruan G; S. Li, PhD, P. Cao, PhD, G. Ruan, PhD, Y. Zhang, PhD, Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
  • Zhang Y; S. Li, PhD, P. Cao, PhD, G. Ruan, PhD, Y. Zhang, PhD, Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
  • Zeng Q; Q. Zeng, MD, Z. He, MD, S. Li, BS, R. Chen, BM, P. Zheng, MD, T. Fan, MD, P. Lu, MD, Y. Zhao, MD, G. Huang, MD, Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, and School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China.
  • He Z; Q. Zeng, MD, Z. He, MD, S. Li, BS, R. Chen, BM, P. Zheng, MD, T. Fan, MD, P. Lu, MD, Y. Zhao, MD, G. Huang, MD, Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, and School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China.
  • Li S; Q. Zeng, MD, Z. He, MD, S. Li, BS, R. Chen, BM, P. Zheng, MD, T. Fan, MD, P. Lu, MD, Y. Zhao, MD, G. Huang, MD, Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, and School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China.
  • Chen R; Q. Zeng, MD, Z. He, MD, S. Li, BS, R. Chen, BM, P. Zheng, MD, T. Fan, MD, P. Lu, MD, Y. Zhao, MD, G. Huang, MD, Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, and School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China.
  • Zheng P; Q. Zeng, MD, Z. He, MD, S. Li, BS, R. Chen, BM, P. Zheng, MD, T. Fan, MD, P. Lu, MD, Y. Zhao, MD, G. Huang, MD, Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, and School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China.
  • Fan T; Q. Zeng, MD, Z. He, MD, S. Li, BS, R. Chen, BM, P. Zheng, MD, T. Fan, MD, P. Lu, MD, Y. Zhao, MD, G. Huang, MD, Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, and School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China.
  • Lu P; Q. Zeng, MD, Z. He, MD, S. Li, BS, R. Chen, BM, P. Zheng, MD, T. Fan, MD, P. Lu, MD, Y. Zhao, MD, G. Huang, MD, Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, and School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China.
  • Zhao Y; Q. Zeng, MD, Z. He, MD, S. Li, BS, R. Chen, BM, P. Zheng, MD, T. Fan, MD, P. Lu, MD, Y. Zhao, MD, G. Huang, MD, Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, and School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China.
  • Englund M; M. Englund, PhD, Department of Clinical Sciences Lund, Orthopedics, Clinical Epidemiology Unit, Faculty of Medicine, Lund University, Lund, Sweden.
  • Madry H; H. Madry, PhD, Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg, Germany.
  • Huang G; Q. Zeng, MD, Z. He, MD, S. Li, BS, R. Chen, BM, P. Zheng, MD, T. Fan, MD, P. Lu, MD, Y. Zhao, MD, G. Huang, MD, Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, and School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China.
  • Li L; Z. Gong, BS, L. Li, PhD, Institute of Medical Research, Northwestern Polytechnical University, Xi'an, China.
  • Li J; J. Li, PhD, Division of Orthopaedic Surgery, Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, China; Changhai.Ding@utas.edu.au nylijia5@smu.edu.cn.
  • Ding C; C. Ding, PhD, Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China, and Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia. Changhai.Ding@utas.edu.au nylijia5@smu.edu.cn.
J Rheumatol ; 50(4): 548-555, 2023 04.
Article em En | MEDLINE | ID: mdl-36521912
ABSTRACT

OBJECTIVE:

The aim of this study was to explore the association between quadriceps strength and synovitis in knee osteoarthritis (KOA).

METHODS:

This study was derived from the Osteoarthritis Initiative (OAI), which recruited adults from the OAI cohort with or at risk of KOA. Knees with complete records of isometric quadriceps strength and effusion-synovitis and Hoffa-synovitis assessments were included. Quadriceps strength was measured isometrically at baseline. Effusion-synovitis and Hoffa-synovitis were measured using the Magnetic Resonance Imaging Osteoarthritis Knee Score at baseline and at 1-year and 2-year follow-ups. Generalized estimating equations were used to analyze the associations of baseline quadriceps strength with changes in effusion-synovitis and Hoffa-synovitis in multivariable analyses. Additionally, analyses were stratified by synovitis-driven inflammatory phenotypes.

RESULTS:

A total of 1513 knees were included in this study. In total, 61% of the subjects were female; subjects had an average age of 61.9 (SD 8.8) years and a mean BMI of 29.4 (SD 4.7). Regarding the whole population, baseline quadriceps strength was negatively associated with baseline effusion-synovitis and follow-up changes in effusion-synovitis (odds ratio [OR] 0.77-0.86), but no significant association was observed in terms of Hoffa-synovitis. Stratified by synovitis-driven inflammatory phenotype, baseline quadriceps strength was significantly associated with follow-up changes in effusion-synovitis-but not in Hoffa-synovitis-in the population with existing effusion-synovitis (OR 0.75-0.79).

CONCLUSION:

Higher baseline quadriceps strength was negatively associated with changes in effusion-synovitis-but not in Hoffa-synovitis-especially in the population with existing effusion-synovitis. Our findings suggested a potential protective role of the quadriceps in effusion-synovitis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sinovite / Osteoartrite do Joelho Tipo de estudo: Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: J Rheumatol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sinovite / Osteoartrite do Joelho Tipo de estudo: Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: J Rheumatol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China