Photocatalytic Generation of Hydrogen Radical (Hâ
) with GSH for Photodynamic Therapy.
Angew Chem Int Ed Engl
; 62(9): e202214991, 2023 02 20.
Article
em En
| MEDLINE
| ID: mdl-36537886
ABSTRACT
As a reactive hydrogen species, the hydrogen radical (Hâ
) scarcely sees applications in tumor biological therapy due to the very limited bio-friendly sources of Hâ
. In this work, we report that TAF can act as an organic photosensitizer as well as an efficient photocatalytic Hâ
generator with reduced glutathione (GSH) as a fuel. The photoactivation of TAF leads to cell death in two ways including triple amplification of oxidative stress via ferroptosis-apoptosis under normoxia and apoptosis through biological reductions under hypoxia. TAF presents excellent biosafety with ultrahigh photocytotoxicity index at an order of magnitude of 102 -103 on both normoxic and hypoxic cells. The in vitro data suggest that Hâ
therapy is promising to overcome the challenge of tumor hypoxia at low doses of both photocatalyst and light. In addition, the capability of near-infrared two-photon excitation would benefit broad biological applications.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fotoquimioterapia
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2023
Tipo de documento:
Article