Crystal structure of LGR ligand &#945;2/ß5 from <i>Caenorhabditis elegans</i> with implications for the evolution of glycoprotein hormones.

Gong, Zhen; Wang, Wei; El Omari, Kamel; Lebedev, Andrey A; Clarke, Oliver B; Hendrickson, Wayne A

Crystal structure of LGR ligand α2/ß5 from Caenorhabditis elegans with implications for the evolution of glycoprotein hormones.

Gong, Zhen; Wang, Wei; El Omari, Kamel; Lebedev, Andrey A; Clarke, Oliver B; Hendrickson, Wayne A.

Afiliação

Gong Z; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.
Wang W; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.
El Omari K; Diamond Light Source, Harwell Science & Innovation Campus, Didcot OX11 0DE, UK.
Lebedev AA; CCP4, STFC Rutherford Appleton Laboratory, Didcot OX11 0QX, UK.
Clarke OB; Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032.
Hendrickson WA; Department of Anesthesiology, Columbia University, New York, NY 10032.

Proc Natl Acad Sci U S A ; 120(1): e2218630120, 2023 01 03.

Article em En | MEDLINE | ID: mdl-36574673

Assuntos

Caenorhabditis elegans; Glicoproteínas; Hormônios; Receptores Acoplados a Proteínas G; Animais; Sequência de Aminoácidos; Caenorhabditis elegans/genética; Caenorhabditis elegans/metabolismo; Ligantes; Receptores Acoplados a Proteínas G/genética

Palavras-chave

cystine-knot hormone (CKH); evolution; glycoprotein hormone (GPH); leucine-rich-repeat-containing G-protein-coupled receptor (LGR); thyrostimulin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas / Caenorhabditis elegans / Receptores Acoplados a Proteínas G / Hormônios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article

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