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Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes.
Lin, Yun Hsuan; Duong, Han G; Limary, Abigail E; Kim, Eleanor S; Hsu, Paul; Patel, Shefali A; Wong, William H; Indralingam, Cynthia S; Liu, Yi Chia; Yao, Priscilla; Chiang, Natalie R; Vandenburgh, Sara A; Anderson, Taylor R; Olvera, Jocelyn G; Ferry, Amir; Takehara, Kennidy K; Jin, Wenhao; Tsai, Matthew S; Yeo, Gene W; Goldrath, Ananda W; Chang, John T.
Afiliação
  • Lin YH; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • Duong HG; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • Limary AE; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • Kim ES; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • Hsu P; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • Patel SA; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • Wong WH; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • Indralingam CS; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • Liu YC; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • Yao P; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • Chiang NR; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • Vandenburgh SA; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • Anderson TR; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • Olvera JG; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • Ferry A; Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
  • Takehara KK; Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
  • Jin W; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • Tsai MS; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • Yeo GW; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • Goldrath AW; Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA.
  • Chang JT; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA; Department of Medicine, Jennifer Moreno Department of Veteran Affairs Medical Center, San Diego, CA 92161, USA. Electronic address: changj@ucsd.edu.
Immunity ; 56(1): 207-223.e8, 2023 01 10.
Article em En | MEDLINE | ID: mdl-36580919
ABSTRACT
Tissue-resident memory CD8+ T (TRM) cells are a subset of memory T cells that play a critical role in limiting early pathogen spread and controlling infection. TRM cells exhibit differences across tissues, but their potential heterogeneity among distinct anatomic compartments within the small intestine and colon has not been well recognized. Here, by analyzing TRM cells from the lamina propria and epithelial compartments of the small intestine and colon, we showed that intestinal TRM cells exhibited distinctive patterns of cytokine and granzyme expression along with substantial transcriptional, epigenetic, and functional heterogeneity. The T-box transcription factor Eomes, which represses TRM cell formation in some tissues, exhibited unexpected context-specific regulatory roles in supporting the maintenance of established TRM cells in the small intestine, but not in the colon. Taken together, these data provide previously unappreciated insights into the heterogeneity and differential requirements for the formation vs. maintenance of intestinal TRM cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD8-Positivos / Células T de Memória Idioma: En Revista: Immunity Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD8-Positivos / Células T de Memória Idioma: En Revista: Immunity Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos