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Publication bias in pharmacogenetics of adverse reaction to antiseizure drugs: An umbrella review and a meta-epidemiological study.
Bally, S; Cottin, J; Gagnieu, M C; Lega, J C; Verstuyft, C; Rheims, S; Lesca, G; Cucherat, M; Grenet, Guillaume.
Afiliação
  • Bally S; Laboratoire de Biométrie et Biologie Evolutive UMR5558, Université Lyon 1, CNRS, Villeurbanne, France.
  • Cottin J; Service Hospitalo-Universitaire de Pharmacotoxicologie, Pôle de Santé Publique, Hospices Civils de Lyon, Lyon, France.
  • Gagnieu MC; Laboratoire de Pharmacologie, Groupement Hospitalier Sud, Hospices Civils De Lyon, Lyon, France.
  • Lega JC; Laboratoire de Biométrie et Biologie Evolutive UMR5558, Université Lyon 1, CNRS, Villeurbanne, France.
  • Verstuyft C; Service de Médecine Interne et Vasculaire, Hôpital Lyon Sud, Hospices Civils de Lyon, Lyon, France.
  • Rheims S; CESP, MOODS Team, INSERM, Faculté de Médecine, Université Paris-Saclay, Le Kremlin Bicêtre, France.
  • Lesca G; Service de Génétique Moléculaire, Pharmacogénétique et Hormonologie de Bicêtre, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.
  • Cucherat M; Department of Functional Neurology and Epileptology, Hospices Civils de Lyon, Lyon 1 University, Lyon, France.
  • Grenet G; Service de Génétique, Groupement Hospitalier Est, Hospices Civils De Lyon, Université Lyon 1, Lyon, France.
PLoS One ; 17(12): e0278839, 2022.
Article em En | MEDLINE | ID: mdl-36584134
ABSTRACT
Publication bias may lead to a misestimation in the association between pharmacogenetic biomarkers (PGx) and antiseizure drug's adverse effects (AEs). We aimed to assess its prevalence in this field. We searched for systematic reviews assessing PGx of antiseizure drug's AEs. For each unique association between a PGx, a drug and its AE, we used the available odds ratio (ORs) to generate corresponding funnel plots. We estimated the prevalence of publication bias using visual inspections and asymmetry tests. We explored the impact of publication bias using ORs adjusted for potential publication bias. Twenty-two associations were available. Our visual analysis suggested a publication bias in five out twenty-two funnel plots (23% [95%CI 8; 45]). The Egger's test showed a significant publication bias in one (HLA-B*1502 and phenytoin-induced Stevens-Johnson syndrome or toxic epidermal necrolysis, p = 0.03) out of nine (11% [95%CI 0; 48]) and the Begg's test in one (HLA-B*1502 and carbamazepine-induced serious cutaneous reactions, p = 0.02) out of ten (10% [95%CI 0; 45]) assessable funnel plots. Adjusting for publication bias may reduce by half the ORs of the pharmacogenetics associations. Publication bias in the pharmacogenetic of antiseizure drug's AEs is not uncommon and may affect the estimation of the effect of such biomarkers. When conducting pharmacogenetic studies, it is critical to publish also the negative one.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Farmacogenética / Síndrome de Stevens-Johnson Tipo de estudo: Observational_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Farmacogenética / Síndrome de Stevens-Johnson Tipo de estudo: Observational_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: França