[New mechanisms of chronic kidney disease-associated vascular calcification].
Sheng Li Xue Bao
; 74(6): 913-926, 2022 Dec 25.
Article
em Zh
| MEDLINE
| ID: mdl-36594380
ABSTRACT
Vascular calcification is the crucial factor of high cardiovascular disease morbidity and mortality in patients with chronic kidney disease (CKD), which causes a huge medical and economic burden. It is urgent to explore its pathogenesis and intervention methods. CKD-associated vascular calcification is an ectopic osteogenesis process actively regulated by multiple cells. Vascular smooth muscle cells (VSMCs) undergo osteogenic differentiation in a pro-calcification environment, and secrete matrix vesicles to form calcium and phosphorus crystal deposition sites, which are key events in the development of CKD-associated vascular calcification. This article reviews the new mechanism and technology of CKD-associated vascular calcification and discusses the role of the myokine Irisin in CKD-associated vascular calcification.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Insuficiência Renal Crônica
/
Calcificação Vascular
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
Zh
Revista:
Sheng Li Xue Bao
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China