Blockade of CB1 or Activation of CB2 Cannabinoid Receptors Is Differentially Efficacious in the Treatment of the Early Pathological Events in Streptozotocin-Induced Diabetic Rats.

Spyridakos, Dimitris; Mastrodimou, Niki; Vemuri, Kiran; Ho, Thanh C; Nikas, Spyros P; Makriyannis, Alexandros; Thermos, Kyriaki

Spyridakos, Dimitris; Mastrodimou, Niki; Vemuri, Kiran; Ho, Thanh C; Nikas, Spyros P; Makriyannis, Alexandros; Thermos, Kyriaki.

Afiliação

Spyridakos D; Department of Pharmacology, School of Medicine, University of Crete, 71003 Heraklion, Greece.
Mastrodimou N; Department of Pharmacology, School of Medicine, University of Crete, 71003 Heraklion, Greece.
Vemuri K; Center for Drug Discovery, Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.
Ho TC; Center for Drug Discovery, Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.
Nikas SP; Center for Drug Discovery, Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.
Makriyannis A; Center for Drug Discovery, Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.
Thermos K; Department of Pharmacology, School of Medicine, University of Crete, 71003 Heraklion, Greece.

Int J Mol Sci ; 24(1)2022 Dec 23.

Article em En | MEDLINE | ID: mdl-36613692

Assuntos

Diabetes Mellitus Experimental; Retinopatia Diabética; Receptor CB1 de Canabinoide; Receptor CB2 de Canabinoide; Animais; Ratos; Canabinoides/farmacologia; Canabinoides/uso terapêutico; Diabetes Mellitus Experimental/tratamento farmacológico; Retinopatia Diabética/tratamento farmacológico; Receptor CB1 de Canabinoide/antagonistas & inibidores; Receptor CB2 de Canabinoide/agonistas; Rimonabanto; Estreptozocina

Palavras-chave

cannabinoid receptors; early stage diabetic retinopathy; endocannabinoid system; eye drops; neurodegeneration; neuroinflammation; neuroprotection; nitrative stress; vascular leakage

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor CB1 de Canabinoide / Receptor CB2 de Canabinoide / Diabetes Mellitus Experimental / Retinopatia Diabética Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Grécia

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