Target-Specific Nanoparticle Polyplex Down-Regulates Mutant <i>Kras</i> to Prevent Pancreatic Carcinogenesis and Halt Tumor Progression.

Smith, Jill P; Chen, Wenqiang; Shivapurkar, Narayan; Gerber, Monica; Tucker, Robin D; Kallakury, Bhaskar; Dasa, Siva Sai Krishna; Kularatne, Ruvanthi N; Stern, Stephan T

Target-Specific Nanoparticle Polyplex Down-Regulates Mutant Kras to Prevent Pancreatic Carcinogenesis and Halt Tumor Progression.

Smith, Jill P; Chen, Wenqiang; Shivapurkar, Narayan; Gerber, Monica; Tucker, Robin D; Kallakury, Bhaskar; Dasa, Siva Sai Krishna; Kularatne, Ruvanthi N; Stern, Stephan T.

Afiliação

Smith JP; Department of Medicine, Georgetown University, Washington, DC 20007, USA.
Chen W; Department of Medicine, Georgetown University, Washington, DC 20007, USA.
Shivapurkar N; Department of Medicine, Georgetown University, Washington, DC 20007, USA.
Gerber M; Department of Medicine, Georgetown University, Washington, DC 20007, USA.
Tucker RD; Department of Pathology, Georgetown University, Washington, DC 20007, USA.
Kallakury B; Department of Pathology, Georgetown University, Washington, DC 20007, USA.
Dasa SSK; Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, Frederick, MD 21702, USA.
Kularatne RN; Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, Frederick, MD 21702, USA.
Stern ST; Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, Frederick, MD 21702, USA.

Int J Mol Sci ; 24(1)2023 Jan 01.

Article em En | MEDLINE | ID: mdl-36614194

Assuntos

Carcinoma in Situ; Carcinoma Ductal Pancreático; Neoplasias Pancreáticas; Camundongos; Humanos; Animais; Proteínas Proto-Oncogênicas p21(ras)/genética; Proteínas Proto-Oncogênicas p21(ras)/metabolismo; Modelos Animais de Doenças; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/prevenção & controle; Pâncreas/metabolismo; Carcinogênese/genética; Carcinogênese/patologia; Carcinoma in Situ/genética; Carcinoma Ductal Pancreático/patologia; Neoplasias Pancreáticas

Palavras-chave

cholecystokinin receptor; mutant Kras; nanoparticles; pancreatic cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Carcinoma in Situ / Carcinoma Ductal Pancreático Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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