Role of microRNA-regulated cancer stem cells in recurrent hepatocellular carcinoma.
World J Hepatol
; 14(12): 1985-1996, 2022 Dec 27.
Article
em En
| MEDLINE
| ID: mdl-36618329
ABSTRACT
Among the most common cancers, hepatocellular carcinoma (HCC) has a high rate of tumor recurrence, tumor dormancy, and drug resistance after initial successful chemotherapy or radiotherapy. A small subset of cancer cells, cancer stem cells (CSCs), exhibit stem cell characteristics and are present in various cancers, including HCC. The dysregulation of microRNAs (miRNAs) often accompanies the occurrence and development of HCC. miRNAs can influence tumorigenesis, progression, recurrence, and drug resistance by regulating CSCs properties, which supports their clinical utility in managing and treating HCC. This review summarizes the regulatory effects of miRNAs on CSCs in HCC with a special focus on their impact on HCC recurrence.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
World J Hepatol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Nova Zelândia