<i>N</i>-Heterocyclic Carbene-Catalyzed Enantioselective [3 + 2] Annulation of Enals with Vinyl Ketones.

Azaz, Tazeen; Mourya, Hemlata; Singh, Vikram; Ram, Bali; Tiwari, Bhoopendra

N-Heterocyclic Carbene-Catalyzed Enantioselective [3 + 2] Annulation of Enals with Vinyl Ketones.

Azaz, Tazeen; Mourya, Hemlata; Singh, Vikram; Ram, Bali; Tiwari, Bhoopendra.

Afiliação

Azaz T; Department of Biological and Synthetic Chemistry, Centre of Biomedical Research, SGPGIMS-Campus, Raebareli Road, Lucknow, Uttar Pradesh 226014, India.
Mourya H; Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India.
Singh V; Department of Biological and Synthetic Chemistry, Centre of Biomedical Research, SGPGIMS-Campus, Raebareli Road, Lucknow, Uttar Pradesh 226014, India.
Ram B; Department of Biological and Synthetic Chemistry, Centre of Biomedical Research, SGPGIMS-Campus, Raebareli Road, Lucknow, Uttar Pradesh 226014, India.
Tiwari B; Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India.

J Org Chem ; 88(2): 1219-1226, 2023 Jan 20.

Article em En | MEDLINE | ID: mdl-36622160

ABSTRACT

ABSTRACT

An unprecedented N-heterocyclic carbene (NHC)-catalyzed enantioselective [3 + 2] annulation of enals with vinyl ketones has been achieved. Unlike chalcones, the ß-unsubstituted enones, namely, vinyl ketones, have remained challenging in terms of reactivity, especially enantioselectivity. The disubstituted cyclopentenes were obtained in good yields and excellent stereoselectivities in the presence of Ti(OiPr)4.

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Índia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google