1,2-Diamination of Alkenes via 1,3-Dipolar Cycloaddition with Azidium Ions or Azides.
Org Lett
; 25(2): 331-335, 2023 Jan 20.
Article
em En
| MEDLINE
| ID: mdl-36626894
ABSTRACT
We describe two new methods for the 1,2-diamination of alkenes. First, either an azidium ion (ArNâN+âNAr) undergoes 1,3-dipolar cycloaddition with an alkene to give a 1,2,3-triazolinium ion directly, or an intramolecular azide-alkene cycloaddition followed by N-benzylation provides the same. Second, hydrogenation of the 1,2,3-triazolinium ion over Raney Ni excises the central N atom and gives the 1,2-diamine. The stereochemistry of the alkene is usually, but not always, preserved in the 1,2-diamine.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos